Table of Contents

A Brief Review on Glucosamine:

Glucosamine plays a very important role in building cartilage, so many people take it as a supplement that helps to treat osteoarthritis and arthritis. It naturally falls in the fluid around the joints, bone marrow, animal bones, fungi, and shellfish.
Glucosamine, especially glucosamine sulfate 1500mg, is taken out from the shells of shellfish to make a dietary supplement. It’s a synthetic form which also made in laboratories.

In this research article, we must explain what glucosamine reviews are, why it’s taken as supplements and is there any scientific evidence that proves whether it’s effective or not, and we also discuss on Glucosamine side effects and also about its warnings that come with glucosamine.

What is Glucosamine?
Glucosamine basically it’s taken by mouth and comes in several forms, in which including:

Glucosamine comes in many numbers of forms.
Glucosamine sulphate 1500mg ,1000mg, 500mg
Glucosamine pills in a bottle
Glucosamine hydrochloride

These all variants can have different effects when you take as dietary supplements.

In some of the dietary supplements, glucosamine pills may be merged with other ingredients, including glucosamine and chondroitin, shark cartilage, and MSM.

Chondroitin is known as a similar substance to glucosamine and consists naturally in joints as well.

Some of the peoples claim that the combinations in these supplements can help, but researchers state that the proof of science is lacking.

Today most of the studies into the likely health benefits of Glucosamine focus on the sulfate.

One important advise we mentioned here before we go further more in detail if you buying these supplements than you must buy it from reputable outlets or registered pharmacy. The National Institutes of Health {NIH} in the U.S point out that glucosamine sulfate products do not contain the ingredients listed as the same on their label.

Several more tests have shown that the glucosamine content can be range from 0-100 percent. In some other cases, the labels must claim that the products contain glucosamine hydrochloride, but in fact, glucosamine sulfate.

Glucosamine Function:
Glucosamine is very well known for building cartilage. And Cartilage is a tough, flexible connective tissue which found in several parts of the human body. The rubbery tissue functions as filling at the ends of long bones where they meet with the joints.

As of our age, the cartilage can steadily breakdown and can become less flexible. There is some evidence that shows that glucosamine might slow this process.

Some of the scientists believe that it is sulfur in glucosamine that this ingredient beneficial for cartilage health. Sulfur must be absorbed into cartilage to build and repair it as well. Naturally, Glucosamine plays a vital role in the incorporation of sulfur into cartilage.

As depending on the people age, the level of glucosamine falls. So, in some time, this may play a role in joint worsening.

The according to the National Center from the U.S for Complementary and Alternative-Therapy, research which reported 2007 National Health Interview Survey founded that 17.7 % of adults in the United States of America took some type of dietary supplement on regular basis.

Of those, 20% took glucosamine. So in this way, this supplement was known as the 2nd most popular dietary supplement after omega 3, fish oil or DHA, which were taken by 37.4 percent of those peoples who took supplements.

The National Center of Health lists the following reasons below, that why people like to use glucosamine sulphate:



interstitial cystitis, a bladder conditions
weight loss
osteoarthritis (OA)
joint pain, such as knee pain
back pain
jaw pain
multiple sclerosis (MS)
Glucosamine supplements are also used by those peoples who are with ulcerative colitis and inflammatory bowel disease (IBD).

Is Glucosamine help with the Osteoarthritis?
Several peoples take glucosamine supplements for Osteoarthritis OA, and especially Osteoarthritis of the hip or knee.

Some of the studies suggest that glucosamine pills may have the following effects below:

Reduce osteoarthritis-related pain, stiffness, and even swelling in the joints.
Improve function in people who have a problem with knee or hip osteoarthritis.
Also, it provides continued relief of symptoms for up to three months after someone stops treatment.
The Glucosamine Chondroitin Arthritis Intervention Trial (GAIT) surveyed the 1600 participants which belong in 16 locations across the U.S. and found that glucosamine chondroitin sulfate didn’t give significant relief from osteoarthritis.

Some of the participants with moderate to severe pain reported to the significant relief, when they took the merger of glucosamine and chondroitin.

While this mergers, or Glucosamine alone, may also relieve-moderate to severe pains in people with osteoporosis, so overall, it appears to be not more effective than a placebo in lessening the loss of cartilage in the knee osteoarthritis.

Arthritis Research Center U.K. gives scores glucosamine two out of five for the effectiveness in treating the symptoms of osteoarthritis, and glucosamine hydrochloride one out of five, where five is the most effective. These scores are based on the reviews of so many trials.

The reviews of 18 trials in 2005, some of the results indicated that glucosamine or glucosamine sulphate might be a benefit for the peoples with osteoarthritis, while the others didn’t find it effective.

The review of 2 trials for glucosamine hydrochloride in the year 2010 didn’t reveal even a clinically significant improvement in the joint pain or in the osteoarthritis condition.

The National Institute of Health, they point out that some people while use creams that containing glucosamine for arthritis pain, these Glucosamine gel creams include other substances, such as camphor. It might be these types of additional substances that relieve the pain, and there is such no evidence that glucosamine can be absorbed through or by the skin.

Some Other Uses:
Some studies have analyzed that Glucosamine may help people with irritable bowel disease (IBD).

Elsewhere, the scientists from the University of California found that N-acetyl Glucosamine (GlcNAc) supplements repressed the damaging of an autoimmune response that occurs in the MS.

It shows that GlcNAc may inhibit the function and growth of abnormal T-cells that mistakes can cause a person’s immune system to destroy and attack myelin, the tissue which insulates the body’s nerves.

These findings were supported by the Jefferson Medical College. The team found that over-the-counter (OTC) glucosamine helped to delay the onset of MS symptoms in rats and improved in the ability to move and walk.

The further study found that glucosamine may also have carried over effect when it used with ibuprofen to reduce the level of the pain in people with temporomandibular joint (TMJ) problems.

The Evidence:
Glucosamine is recommended for a huge range of illnesses and on other physical conditions, but studies have found it ineffective or even harmful to the people with some different allergies.

There is no evidence, E.g, that it can help or cannot help the people with chronic lower back pain and with a sports injury.

There are no scientific studies to claim that glucosamine is either beneficial or not for people with venous insufficiency, which affects the blood flow in the human legs.

The American Family Physician strictly warns that people with asthma should use glucosamine because it has been linked with the people breathing problem.

Glucosamine Side Effects:
The Glucosamine side effects are reported to be infrequent and mild, but they can also include:

stomach upsets

The National Institute of Health notes that glucosamine is likely safe when used it in a correct way by the adults, but some people have little bit experienced mild side effects, which including skin reactions, drowsiness, and headache.

The effect of glucosamine during breastfeeding or pregnancy is unknown, so it’s not advisable to use it at this time period.

It’s Risks:
Whether glucosamine raises blood glucose levels in people who suffered from diabetes, but research studies claim that two types of diabetes, it probably does not.

Some of the people take glucosamine to treat allergies, but glucosamine products derived from the shellfish and may cause trigger allergies in anyone who is susceptible. The people who suffered from a shellfish allergy are hardly advised please to avoid this type of glucosamine supplements.

In conclusion:
Glucosamine is relatively safe for the human body when taken as advice or contact to your reliable specialist, by adults those without allergies or asthma. So, however, the evidence for the ability to treat joint pain complaints and other physical conditions is currently lacking. so be careful before it and consult with a well-known doctor.